Clonal selection theory is a scientific theory in immunology that explains the functions of cells of the immune system (lymphocytes) in response to specific antigens invading the body. For example, lymphoid-primed multipotential precursors (LMPP) still maintain some myeloid potential but ultimately produce lymphoid progeny. Although significant progress has been made in context of delineating the pathways that lead to their development, maturity and differentiation, their detailed mechanisms are yet to be dissected out completely. As described in Part 1, lymphocytes are generated in the bone marrow from a single progenitor cell line. The concept was introduced by Australian doctor Frank Macfarlane Burnet in 1957, in an attempt to explain the great diversity of antibodies formed during initiation of the immune response. Some lymphocytes work alone, while others are able to coordinate with other cells. Lymphocyte development is a highly regulated process in which immature lymphoid progenitors are generated from HSCs and then mature through defined stages of differentiation. the bone marrow for B-cell development; the thymus for T-cell development; VDJ recombination in order to . The development stages of GC B cells are based on the relative expression of IgD and CD38 on mature B (Bm) lymphocytes from naïve cells leaving the BM (Bm1) to memory B cells activated and differentiated by their specific antigen (Bm5). A particular The diversity of BCRs is generated by V(D)J recombination, somatic hypermutation (SHM), and class switch recombination (CSR) during B cell development and differentiation 31,32. rearrange genetic material View (9)Lymphocyte development_2020.pdf from CHEM PHYSICAL C at 한국외국어대학교. The development of lymphocytes starts with the common lymphoid progenitor derived from ... called V (variable), D (diversity), J (joining) and C (constant) gene segments. 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