The nucleus stains a pale bluish-violet, and the chromatin is fine. MONOCYTE. However, the chromatin of monocytes is less dense than neutrophils, and is ⦠Characterized by a horseshoe-shaped nucleus - However, the nucleus is not lobed Lymphocytes. In the production of lymphocytes, the hemocytoblast first differentiates to produce the lymphoid stem cell. Monocytes have generally lighter staining nuclei than do other leukocytes. Monocytes have a diameter of 18 μm and are the largest of the white blood cells present in a blood smear. The cytoplasm often appears uneven and the cytoplasmic margins are sprawling. Notes: Monocyte nuclear and cytoplasmic morphology can be highly variable. Can be identified by the shape of their nucleus. Both the size and shape of the nucleus are useful indicators when differentiating them from lymphocytes which are about half their size and have a less indented nucleus. Granulocytes are a category of white blood cells in the innate immune system characterized by the presence of specific granules in their cytoplasm. No pigments (colorless). Primary function: Defense, immunity. The nuclear shape in monocytes varies and may be round, oval, indented, or lobulated. They are also called polymorphonuclear leukocytes (PMN, PML, or PMNL) because of the varying shape of the nucleus, which is usually lobed into three segments.This distinguishes them from the mononuclear agranulocytes. Overall, the nucleus has a soft, spongy, three-dimensional appearance, in contrast to the hard, flat nucleus of the large lymphocyte and the densely clumped nucleus of the band. Can squeeze through capillary walls. Prominent nucleolus. Cytoplasm: 1,2 Blue-gray cytoplasm (Ground glass appearance due ⦠A lymphocyte nucleus appears rigid. Positively chemotaxic - attracted to certain chemicals. Lymphocyte chromatin looks to be colored in heavy crayon. These cells leave the blood stream (diapedesis) to become macrophages. The nucleus appears squishy. Have nucleus & mitochondria. Polymorphonuclear cells have a nucleus which has several segments or lobes while mononuclear cells have a round shape nucleus. Monocytes. Scant cytoplasm. The nucleus can be round to kidney-shaped to pseudo-lobulated (can mimic a neutrophil). The nucleus most often is reniform, but may be round or irregular. Most are phagocytic. be seen in monocytes, as in this example. Have amoeboid ability (move like amoeba). Monocytes too may be confused with reactive lymphocytes. Formed in bone marrow. Thus, this is the key difference between polymorphonuclear and mononuclear cells. Monocyte chromatin is more linear and dark, looking like smudged pencil lines. Monocytes are slightly larger than neutrophils at 12 - 20 μm, have abundant gray-blue cytoplasm and an indented nucleus ⦠1 Nucleus-to-Cytoplasm Ratio: Variable 2 Nucleoli: Not visible 2 Nucleus: 1,2 Variable shapes (Folds, kidney shaped) Loose, lacy, violet chromatin . A: Monocytes are usually shaped like a kidney bean due to their large bi-lobular nucleus.The nucleus also stains much less dense than a lymphocyte - 2-10% of WBCs - 2-5 day lifespan in circulation and 1-3 months in tissue - Function as phagocytes Travel through bloodstream. It can even occasionally be band-shaped, especially in dogs, and may be confused with band neutrophils. Chromatin aggregates are arranged along the internal side of the nuclear membrane. Conformable nuclear membrane - the nuclear membrane often conforms to the shape of the cytoplasmic membrane. They are polymorphonuclear cells and mononuclear cells. Leukocytes are two types based on the nucleus structure. 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